产品详情
产品名称EGR1 Antibody
来源种属Rabbit
克隆性Polyclonal
应用ELISA WB
种属反应性Human;Mouse
特异性The antibody detects endogenous level of total EGR1 protein.
免疫原类型Recombinant protein
免疫原描述Fusion protein corresponding to a region derived from 87-337 amino acids of human early growth response 1early growth response 1
基因/蛋白名称EGR1
标记Unconjugated
别名early growth response 1, TIS8, AT225, G0S30, NGFI-A, ZNF225, KROX-24, ZIF-268
数据库入口号Genbank No.: BC073983
Uniprot
BC073983
浓度0.1mg/ml
配方Supplied at 0.8mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
保存Store at -20˚C/1 year
应用详情
Predicted MW: 58kd
ELISA: 1:1000-1:5000
Western blotting: 1:200-1:1000
Gel: 8%SDS-PAGE
Lane1: RAW264.7 cell lysate
Lane2: NIH/3T3 cell lysate
Lysates: 50 ug per lane
Primary antibody: 1/400dilution
Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution
Exposure time: 2 minutes
EGR-1 (Early growth response protein 1) also known as Zif268 (zinc finger protein 225) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene. The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site).
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et al,PRIMA-1Met/APR-246 displays high antitumor activity in multiple myeloma by induction of p73 and Noxa. In Mol Cancer Ther on 2013 Nov by Hua Jiang, Yijun Yang, et al..PMID: 24030633
, (2013),
PMID:
24030633
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