产品详情
产品名称RELA Antibody
来源种属Rabbit
克隆性Polyclonal
应用ELISA WB
种属反应性Human
特异性The antibody detects endogenous level of total RELA protein.
免疫原类型Recombinant protein
免疫原描述Full length fusion protein
基因/蛋白名称RELA
标记Unconjugated
别名v-rel reticuloendotheliosis viral oncogene homolog A (avian), p65, NFKB3
数据库入口号Genbank No.: BC011603
Uniprot
BC011603
配方Supplied at 1mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
保存Store at -20˚C/1 year
应用详情
Predicted MW: 25kd
ELISA: 1:2000-1:5000
Western blotting: 1:500-1:2000
Gel: 10%SDS-PAGE
Lane1: 293T cell lysate
Lane2: K562 cell lysate
Lane3: Jurkat cell lysate
Lysates: 40 ug per lane
Primary antibody: 1/500 dilution
Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution
Exposure time: 5 seconds
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
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et al,EGFR-induced and PKC蔚 monoubiquitylation-dependent NF-魏B activation upregulates PKM2 expression and promotes tumorigenesis. In Mol Cell on 2012 Dec 14 by
Weiwei Yang, Yan Xia, et al..PMID: 23123196
, (2012),
PMID:
23123196
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