产品详情
产品名称ADRB2 Antibody
来源种属Rabbit
克隆性Polyclonal
应用ELISA WB IHC
种属反应性Human
特异性The antibody detects endogenous level of total ADRB2 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from 21-33 amino acids of Human adrenoceptor beta 2, surface
基因/蛋白名称ADRB2
标记Unconjugated
别名Adrenoceptor beta 2, surface, BAR, B2AR, ADRBR, ADRB2R, BETA2AR
数据库入口号Genbank No.: NP_000015
Uniprot
NP_000015
配方Supplied at 0.7mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
保存Store at -20˚C/1 year
应用详情
Predicted MW: 46kd
ELISA: 1:1000-1:2000
Western blotting: 1:1000-1:2000
Immunohistochemistry: 1:15-1:50
Gel: 10%SDS-PAGE
Lane1: Hela cell lysate
Lane2: A549 cell lysate
Lysates: 30ug per lane
Primary antibody: 1/600 dilution
Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution
Exposure time: 1 minute
The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using 31142(ADRB2 Antibody) at dilution 1/20, on the right is treated with the synthetic peptide.
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.?
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et al,Aerobic Exercise Inhibits Sympathetic Nerve Sprouting and Restores 尾-Adrenergic Receptor Balance in Rats with Myocardial Infarction.In PLoS One.On 2014 by Ting Chen,Meng-Xin Cai et al..PMID:24842290
, (2014),
PMID:
24842290
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