产品详情
产品名称EDNRB Antibody
来源种属Rabbit
克隆性Polyclonal
应用ELISA WB IHC
种属反应性Human
特异性The antibody detects endogenous level of total EDNRB protein.
免疫原类型Peptide
免疫原描述Synthetic peptide peptide corresponding to a region derived from 70-84 amino acids of human endothelin receptor type B
基因/蛋白名称EDNRB
标记Unconjugated
别名endothelin receptor type B, ETB, ET-B, ETBR, ETRB, HSCR, WS4A, ABCDS, ET-BR, HSCR2
数据库入口号Genbank No.: NP_003982
Uniprot
NP_003982
配方Supplied at 1mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
保存Store at -20˚C/1 year
应用详情
Predicted MW: 50kd
ELISA: 1:2000-1:5000
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:25-1:100
Gel: 10% SDS-PAGE
Lane1: Human fetal lung tissue lysate
Lane2: Human fetal intestine tissue lysate
Lane3: Human lung tissue lysate
Lane4: Hela cell lysate
Lysates: 40ug per lane
Primary antibody: 1/500 dilution
Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/5000 dilution
Exposure time: 1 minute
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 31191 (EDNRB Antibody) at dilution 1/30, on the right is treated with the synthetic peptide.
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
如果您使用该产品31191发表了文章，请通知我们，让我们可以引用您的文献。
et al,Prognostic values of EDNRB in triple-negative breast cancer. In Oncol Lett on 2020 Nov by Shaoqing Liu, Jingyang Zhang, et al..PMID: 32934717
, (2020),
PMID:
32934717
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