产品详情
产品名称P2RY11 Antibody
来源种属Rabbit
克隆性Polyclonal
应用ELISA WB IHC
种属反应性Human
特异性The antibody detects endogenous level of total P2RY11 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from 361-374 amino acids of Human purinergic receptor P2Y, G-protein coupled, 11
基因/蛋白名称P2RY11
标记Unconjugated
别名purinergic receptor P2Y, G-protein coupled, 11, P2Y11
数据库入口号Genbank No.: NP_002557
Uniprot
NP_002557
配方Supplied at 1mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
保存Store at -20˚C/1 year
应用详情
Predicted MW: 40kd
ELISA: 1:1000-1:5000
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:25-1:100
Gel: 10%SDS-PAGE
Lane1: Hela cell lysate
Lane2: 293T cell lysate
Lysates: 40 ug per lane
Primary antibody: 1/500 dilution
Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution
Exposure time: 1 minute
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using 31254 (P2RY11 Antibody) at dilution 1/40, on the right is treated with the synthetic peptide.
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.
如果您使用该产品31254发表了文章，请通知我们，让我们可以引用您的文献。
et al,Inhibition of P2Y11R ameliorated TNF-α-Induced degradation of extracellular matrix In human chondrocytic SW1353 cells. In Am J Transl Res on 2019 Apr 15 by Wang D, LIn N,et al.. PMID: 31105822
, (2019),
PMID:
31105822
有货
