产品详情
产品名称PDX1 Antibody
来源种属Rabbit
克隆性Polyclonal
应用ELISA WB IHC
种属反应性Human
特异性The antibody detects endogenous level of total PDX1 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide peptide corresponding to a region derived from 18-31 amino acids of human pancreatic and duodenal homeobox 1
基因/蛋白名称PDX1
标记Unconjugated
别名pancreatic and duodenal homeobox 1, GSF, IPF1, IUF1, IDX-1, MODY4, PDX-1, STF-1
数据库入口号Genbank No.: NP_000200
Uniprot
NP_000200
配方Supplied at 0.9mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
保存Store at -20˚C/1 year
应用详情
Predicted MW: 31kd
ELISA: 1:2000-1:5000
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:15-1:50
Gel: 10% SDS-PAGE
Lane1: Hela cell lysate
Lane2: Jurkat cell lysate
Lysates: 40ug per lane
Primary antibody: 1/450 dilution
Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/5000 dilution
Exposure time: 1 minute
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using 31259 (PDX1 Antibody) at dilution 1/30, on the right is treated with the synthetic peptide.
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
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et al,Structure characterization of an arabinogalactan from green tea and its anti-diabetic effect.In Carbohydr Polym on 2015 Jun 25 by Huijun Wang , Songshan Shi et al..PMID:25839799
, (2015),
PMID:
25839799
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