产品详情
产品名称SQSTM1 / p62 Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human SQSTM1 / p62 (NP_001135770.1).
标记Unconjugated
别名SQSTM1; A170; DMRV; FTDALS3; NADGP; OSIL; PDB3; ZIP3; p60; p62; p62B; sequestosome-1
数据库入口号Swiss-Prot#:Q13501
NCBI Gene ID:8878
Uniprot
Q13501
计算分子量60kDa
配方Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
IP 1:50 - 1:100
Immunohistochemistry of paraffin-embedded rat brain using SQSTM1 / p62 antibody at dilution of 1:100 (40x lens).
Confocal immunofluorescence analysis of Hela cells using SQSTM1 / p62 Polyclonal antibody at dilution of 1:200. Blue: DAPI for nuclear staining.
Confocal immunofluorescence analysis of U-2 OS cells using SQSTM1 / p62 Polyclonal antibody at dilution of 1:200. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of U2OS cells using SQSTM1 / p62 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of NIH/3T3 using SQSTM1 / p62 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using SQSTM1 / p62 antibody at 1:1000 dilution.
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
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et al,Xinyin tablets affect mitophagy and cardiomyocyte apoptosis to alleviate chronic heart failure by regulating histone deacetylase 3(HDAC3)-mediated PTEN induced putative kinase 1(PINK1)/Parkin signaling pathway.
, (2025),
PMID:
40122315
Yes
