产品详情
产品名称RSPO1 Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human RSPO1 (NP_001033722.1).
标记Unconjugated
别名RSPO1;CRISTIN3;RSPO
数据库入口号Uniprot:Q2MKA7
GeneID:284654
Uniprot
Q2MKA7
Gene ID
284654
计算分子量29kDa
实际分子量29KDa
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:50 - 1:200
Western blot analysis of extracts of SKOV3 cells, using RSPO1 antibody.
Western blot analysis of extracts of Rat pancreas, using RSPO1 antibody.
Immunohistochemistry of paraffin-embedded rat ovary using RSPO1 Rabbit pAb.
Immunofluorescence analysis of A549 cells using RSPO1 Rabbit pAb.
Immunofluorescence analysis of C6 cells using RSPO1 Rabbit pAb.
Immunofluorescence analysis of NIH-3T3 cells using RSPO1 Rabbit pAb.
This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants.
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et al,Prognostic prediction and diagnostic role of Rspondin 1 expression in esophageal squamous cell carcinoma. In Indian J Pathol Microbiol on 2024 Jun 8 by Xiaoxia Cheng, Jiao Liu, et al..PMID:38864442
, (2024),
PMID:
38864442
Yes
