产品详情
产品名称NUDT15 Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human NUDT15 (NP_060753.1).
标记Unconjugated
别名NUDT15; MTH2; NUDT15D; nudix hydrolase 15
数据库入口号Swiss-Prot#:Q9NV35
NCBI Gene ID:55270
Uniprot
Q9NV35
计算分子量19kDa
配方Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:100
Immunohistochemistry of paraffin-embedded human liver using NUDT15 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using NUDT15 antibody at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using NUDT15 antibody at 1:1000 dilution.
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.
如果您使用该产品31526发表了文章，请通知我们，让我们可以引用您的文献。
et al,MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis In Nat CommunOn2023 Aug 10byYangyang Ding , Xiang Gui et al..PMID:37563135
, (2023),
PMID:
37563135
Yes
