产品详情
产品名称SART1 Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human SART1 (NP_005137.1).
标记Unconjugated
别名SART1;Ara1;HOMS1;SART1259;SNRNP110;Snu66;HAF
数据库入口号Uniprot:O43290
GeneID:9092
Uniprot
O43290
Gene ID
9092
计算分子量120kDa
实际分子量120kDa
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using SART1 antibody.
Immunohistochemistry of paraffin-embedded human esophageal using SART1 Rabbit pAb.
Immunohistochemistry of paraffin-embedded mouse kidney using SART1 Rabbit pAb.
Immunohistochemistry of paraffin-embedded rat brain using SART1 Rabbit pAb.
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.
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et al,Expression of interferon effector gene SART1 correlates with interferon treatment response against hepatitis B infection. In Mediators Inflamm on 2016 by Yong Li, Chuanlong Zhu et al..PMID: 28077916
, (2016),
PMID:
28077916
Yes
