产品详情
产品名称ATF4 Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB
种属反应性Human
特异性The antibody detects endogenous level of total ATF4 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human ATF4 (NP_001666.2).
基因/蛋白名称ATF4
标记Unconjugated
别名ATF4;CREB-2;CREB2;TAXREB67;TXREB
数据库入口号Uniprot:P18848
GeneID:468
Uniprot
P18848
Gene ID
468
实际分子量50kDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
Western blot analysis of extracts of HeLa cells, using ATF4 antibody.
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.
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