产品详情
产品名称ATF6 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB IHC IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total ATF6 protein.
免疫原类型Peptide
免疫原描述A synthetic peptide of human ATF6.
基因/蛋白名称ATF6
标记Unconjugated
别名ATF6; ATF6A; Activatingtranscriptionfactor6alpha;
数据库入口号Swiss-Prot:P18850
NCBI Gene ID:22926
Uniprot
P18850
实际分子量75KD
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:200
Immunofluorescence: 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using ATF6 antibody.
Immunohistochemical analysis of paraffin-embedded human lung using ATF6 antibody at dilution of 1:200 (200x lens).
Immunohistochemical analysis of paraffin-embedded human lung cancer using ATF6 antibody at dilution of 1:200 (200x lens).
Immunohistochemical analysis of paraffin-embedded rat lung using ATF6 antibody at dilution of 1:200 (200x lens).
Immunohistochemical analysis of paraffin-embedded rat spleen using ATF6 antibody at dilution of 1:200 (200x lens).
Immunofluorescence analysis of A549 cell using ATF6 antibody. Blue: DAPI for nuclear staining
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
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