产品详情
产品名称BMI1 Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total BMI1 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human Bmi1 (NP_005171.4).
基因/蛋白名称BMI1
标记Unconjugated
别名BMI1;FLVI2/BMI1;PCGF4;RNF51;flvi-2/bmi-1;Bmi1
数据库入口号Uniprot:P35226
GeneID:648
Uniprot
P35226
Gene ID
648
实际分子量43KDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
Western blot analysis of extracts of various cell lines, using Bmi1 Rabbit pAb.
Western blot analysis of extracts of various cell lines, using Bmi1 Rabbit pAb.
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.
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et al,SALL4, a novel marker for human gastric carcinogenesis and metastasis.In Oncogene on 2014 Nov 27 by L Zhang , Z Xu et al..PMID:24276240
, (2014),
PMID:
24276240
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