产品详情
产品名称NAMPT Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB IHC IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total NAMPT protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant protein of human NAMPT.
基因/蛋白名称NAMPT
标记Unconjugated
别名NAMPT; 1110035O14Rik; DKFZp666B131; MGC117256; PBEF
数据库入口号Swiss-Prot:P43490
NCBI Gene ID:10135
Uniprot
P43490
实际分子量52KD
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:200
Immunofluorescence: 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using NAMPT antibody.
Immunohistochemical analysis of paraffin-embedded human ovary cancer using NAMPT antibody.
Immunohistochemical analysis of paraffin-embedded rat spleen using NAMPT antibody at dilution of 1:200 (200x lens).
Immunohistochemical analysis of paraffin-embedded human liver cancer using NAMPT antibody at dilution of 1:200 (200x lens).
Immunofluorescence analysis of HeLa cell using NAMPT antibody.
Nicotinamide phosphoribosyltransferase(NAMPT) has two usual synonyms termed Visfatin and PBEF. Its primary role is to catalyze the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD, which is the rate limiting component in the mammalian NAD biosynthesis pathway. NAMPT is localized in cytoplasm and expressed in large amounts in bone marrow, liver tissue, and muscle tissues. NAMPT inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. NAMPT levels are altered in plasma of patients with type 2 diabetes mellitus (T2DM), and it is now evidenced that NAMPT may plays a role in lipid metabolism.
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et al,Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathwayInJ EthnopharmacolOn2024 Mar 25byXiao Sun?1,?Yunfeng Pan et al..PMID:?38159826
, (2023),
PMID:
38159826
et al,Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathway. In J Ethnopharmacol on 2024 Mar 25 by Xiao Sun, Yunfeng Pan,et al..PMID:38159826
, (2024),
PMID:
38159826
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