产品详情
产品名称IL6 Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total IL6 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human IL6 (NP_000591.1).
基因/蛋白名称IL6
标记Unconjugated
别名IL6;BSF-2;BSF2;CDF;HGF;HSF;IFN-beta-2;IFNB2;IL-6
数据库入口号Uniprot:P05231
GeneID:3569
Uniprot
P05231
Gene ID
3569
实际分子量26KDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Western blot analysis of extracts of Rat lung, using IL6 antibody.
Immunohistochemistry of paraffin-embedded rat spleen using IL6 Rabbit pAb.
Immunohistochemistry of paraffin-embedded mouse spleen using IL6 Rabbit pAb.
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants.
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et al,Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF?κB and MAPK signalling transduction through integrin αVβ3InInt J Mol MedOn2023 OctbyJunlai Wan , Mengwei Li et al..PMID:37654229
, (2023),
PMID:
37654229
et al,Artemisinin alleviates astrocyte overactivation and neuroinflammation by modulating the IRE1/NF-κB signaling pathway in in vitro and in vivo Alzheimer's disease models.
, (2025),
PMID:
39826816
et al,The role of FTO in m6A RNA methylation and immune regulation in Staphylococcus aureus infection-related osteomyelitis.
, (2025),
PMID:
39980685
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