产品详情
产品名称SIRT7 Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total SIRT7 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human SIRT7 (NP_057622.1).
基因/蛋白名称SIRT7
标记Unconjugated
别名SIRT7;SIR2L7;sirtuin 7
数据库入口号Uniprot:Q9NRC8
GeneID:51547
Uniprot
Q9NRC8
Gene ID
51547
实际分子量45KDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using SIRT7 antibody.
Immunofluorescence analysis of U2OS cells using SIRT7 Rabbit pAb.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
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et al,Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy.
, (2025),
PMID:
39908142
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