产品详情
产品名称MyD88 Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total MyD88 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human MyD88 (NP_002459.2).
基因/蛋白名称MyD88
标记Unconjugated
别名MYD88;MYD88D;myeloid differentiation primary response 88;MyD88
数据库入口号Uniprot:Q99836
GeneID:4615
Uniprot
Q99836
Gene ID
4615
实际分子量33KDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using MyD88 antibody.
Immunofluorescence analysis of U2OS cells using MyD88 Rabbit pAb.
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
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et al,Penetrating Macrophage-Based Nanoformulation for Periodontitis Treatment. In ACS Nano on 2022 Nov 22 by Na Yan, Junchao Xu,
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et al,Small molecule inhibitor CRT0066101 inhibits cytokine storm syndrome in a mouse model of lung injury In Int ImmunopharmacolOn2023 JulbyBomiao Cui , Yiying Liu et al..PMID:37182445
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PMID:
37182445
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