产品详情
产品名称HK2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB IHC IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total HK2 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant protein of human HK2.
基因/蛋白名称HK2
标记Unconjugated
别名HK2; DKFZp686M1669; HKII; HXK2;
数据库入口号Swiss-Prot:P52789
NCBI Gene ID:3099
Uniprot
P52789
实际分子量102KD
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:200
Immunofluorescence: 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using HK2 antibody.
Immunofluorescence analysis of U2OS cell using HK2 antibody. Blue: DAPI for nuclear staining.
Hexokinase catalyzes the conversion of glucose to glucose-6-phosphate, the first step in glycolysis. Four distinct mammalian hexokinase isoforms, designated as hexokinase I, II, III, and IV (glucokinase), have been identified. Hexokinases I, II, and III are associated with the outer mitochondrial membrane and are critical for maintaining an elevated rate of aerobic glycolysis in cancer cells (Warburg Effect) (1) in order to compensate for the increased energy demands associated with rapid cell growth and proliferation (2,3).
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et al,CircLARP4 Suppresses Cell Proliferation, Invasion and Glycolysis and Promotes Apoptosis in Non-Small Cell Lung Cancer by Targeting miR-135b. In Onco Targets Ther on 2020 May 4 by Huawei Lu, Qingwei Guo, et al..PMID:32440141
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PMID:
32440141
et al,Multifunctional manganese-based nanogels catalyze immune energy metabolism to promote bone repair
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PMID:
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