产品详情
产品名称NOS1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB,IF
种属反应性Mouse;Rat
特异性The antibody detects endogenous level of total NOS1 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant Protein of human NOS1.
基因/蛋白名称NOS1
标记Unconjugated
别名NOS1; IHPS1; N-NOS; NC-NOS; NOS
数据库入口号Swiss-Prot:P29475
NCBI Gene ID:4842
Uniprot
P29475
实际分子量160KD
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IF 1:20 - 1:50
Western blot analysis of extracts of Rat brain, using NOS1 antibody at 1:500 dilution.
Immunofluorescence analysis of L929 cells using NOS1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Nitric Oxide Synthase (NOS) catalyses the formation of nitric oxide (NO) and citruline from L-arginine, oxygen and cofactors. Three family members have been characterized: neuronal NOS (nNOS), which is found primarily in neuronal tissue; inducible NOS (iNOS), which is induced by interferon gamma and lipopolysaccharides in the kidney and cardiovascular system; and endothelial NOS (eNOS), which is expressed in blood vessels (1). NO is a messenger molecule with diverse functions throughout the body including the maintenance of vascular integrity, homeostasis, synaptic plasticity, long-term potentiation, learning, and memory (2,3).
nNOS binds selectively to the second PDZ domain of PSD-95, and the enzymatic activity of nNOS is either downregulated by phosphorylation at Ser847 by CaM-KII or stimulated by calcium influxes governed by the NMDA receptor channels (4-5).
如果您使用该产品32287发表了文章，请通知我们，让我们可以引用您的文献。
et al,Aerobic Exercise Inhibits Sympathetic Nerve Sprouting and Restores 尾-Adrenergic Receptor Balance in Rats with Myocardial Infarction.In PLoS One.On 2014 by Ting Chen,Meng-Xin Cai et al..PMID:24842290
, (2014),
PMID:
24842290
有货
