产品详情
产品名称KEAP1 Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total KEAP1 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human KEAP1 (NP_036421.2).
基因/蛋白名称KEAP1
标记Unconjugated
别名KEAP1;INrf2;KLHL19
数据库入口号Uniprot:Q14145
GeneID:9817
Uniprot
Q14145
Gene ID
9817
实际分子量60KDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using KEAP1 antibody.
Immunohistochemistry of paraffin-embedded human colon carcinoma using KEAP1 Rabbit pAb.
Immunohistochemistry of paraffin-embedded human esophageal cancer using KEAP1 Rabbit pAb.
Immunofluorescence analysis of C6 cells using KEAP1 Rabbit pAb.
Immunofluorescence analysis of U-2 OS cells using KEAP1 Rabbit pAb.
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
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et al,c-Myc protects hepatocellular carcinoma cell from ferroptosis induced by glutamine deprivation via upregulating GOT1 and Nrf2InMol Biol RepOn2023 AugbyYuxiang Zhao?1,?Yue Wang et al..PMID:?37358765
, (2023),
PMID:
37358765
et al,Association of α-Klotho with regulation of Keap1/Nrf2/Interleukin-1 pathway and AMPA receptor trafficking in the brain of suicide victims. In J Physiol Pharmacol on 2024 Jun by P Panczyszyn-Trzewik, P Misztak,et al..PMID: 39042386
, (2024),
PMID:
39042386
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