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SFTPC Antibody#32459

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产品详情

产品名称SFTPC Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were purified by affinity purification using immunogen.

应用WB IHC IF

种属反应性Human;Mouse;Rat

特异性The antibody detects endogenous level of total SFTPC protein.

免疫原类型Recombinant Protein

免疫原描述Recombinant protein of human SFTPC.

基因/蛋白名称SFTPC

标记Unconjugated

别名SP-C; PSP-C; SFTP2; SMDP2; BRICD6

数据库入口号Swiss-Prot:P11686
NCBI Gene ID:6440

Uniprot P11686

实际分子量21KD

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C

应用详情

Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:100
Immunofluorescence: 1:50 - 1:200

Western blot analysis of extracts of various cell lines, using SFTPC antibody.
Immunofluorescence analysis of U2OS cell using SFTPC antibody. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat heart using SFTPC antibody at dilution of 1:200 (x400 lens)

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.

如果您使用该产品32459发表了文章，请通知我们，让我们可以引用您的文献。

et al,Reduction of Emphysema Severity by Human Umbilical Cord-Derived Mesenchymal Stem Cells in Mice. In Int J Mol Sci on 2022 Aug 10 by Vincent Laiman, Yueh-Lun Lee, et al..PMID:36012176 , (2022),
PMID: 36012176
et al,Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndromeIn Mol MedOn2023 Nov 23byXiao-Yue Chen , Ching Kao et al..PMID:37996782 , (2023),
PMID: 37996782

操作手册

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu人
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk猴
  • Rb兔
  • B牛
  • D狗
  • P猪
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk鸡
;

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