产品详情
产品名称NR0B2 Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total NR0B2 protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from human protein.
基因/蛋白名称NR0B2
标记Unconjugated
别名NR0B2;SHP;SHP1
数据库入口号Uniprot:Q15466
GeneID:8431
Uniprot
Q15466
Gene ID
8431
实际分子量28KDa
浓度1.0mg/ml
配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
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et al,Hsa_circ_0001944 Regulates FXR/TLR4 Pathway and Ferroptosis to Alleviate Nickel Oxide Nanoparticles-Induced Collagen Formation in LX-2 Cells
, (2025),
PMID:
40278581
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