产品详情
产品名称AR Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB
种属反应性Human;Mouse
特异性The antibody detects endogenous level of total AR protein.
免疫原类型Peptide
免疫原描述A synthetic peptide of human Androgen Receptor (NP_000035.2).
基因/蛋白名称AR
标记Unconjugated
别名AIS;AR8;DHTR;HUMARA;HYSP1;KD;NR3C4;SBMA;SMAX1;TFM;AR
数据库入口号Uniprot:P10275
GeneID:367
Uniprot
P10275
Gene ID
367
实际分子量110kDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
Western blot analysis of extracts of 22RV1 cells, using Androgen Receptor Antibody.
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
如果您使用该产品32572发表了文章，请通知我们，让我们可以引用您的文献。
et al,Androgen receptor-induced molecules and androgen contribute synergistically to male-predominance of hepatocellular carcinoma. In iScience on 2024 Jul 15 by Jiayi Zhao, Letian Fang,et al..PMID:39156638
, (2024),
PMID:
39156638
有货
