产品详情
产品名称FGFR2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total FGFR2 protein.
免疫原类型Peptide
免疫原描述A synthetic peptide of human FGFR2.
基因/蛋白名称FGFR2
标记Unconjugated
别名BEK; BFR-1; CD332; CEK3; CFD1
数据库入口号Swiss-Prot:P21802
NCBI Gene ID:2263
Uniprot
P21802
实际分子量79KD
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
IHC 1:50 - 1:200
Immunohistochemistry of paraffin-embedded rat spleen using FGFR2 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human placenta using FGFR2 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse heart using FGFR2 antibody at dilution of 1:100 (40x lens).
Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR1 (flg), FGFR2 (bek, KGFR), FGFR3, and FGFR4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCγ (4,5).
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et al,Paraneoplastic leukocytosis induces NETosis and thrombosis in bladder cancer PDX model. In Am J Cancer Res on 2024 Aug 25
by Yung-Chia Kuo, Chen-Yang Huang,et al..PMID:39267669
, (2024),
PMID:
39267669
et al,A Patient-Derived Orthotopic Xenograft Model of Gastroesophageal-Junction Adenocarcinoma Translated to the Clinic by Tumor-Targeting Fluorescent Antibodies to Carcinoembryonic-Antigen-Related Cell-Adhesion Molecules
, (2021),
PMID:
34182469
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