产品详情
产品名称CASP3 Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB;IHC;IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total CASP3 protein.
免疫原类型Peptide
免疫原描述Recombinant fusion protein of human Caspase-3 (NP_004337.2).
基因/蛋白名称CASP3
标记Unconjugated
别名CPP32;CPP32B;SCA-1;Active Caspase 3;CASP3;active Caspase-3;Caspase 3;Caspase-3 p12;caspase-3
数据库入口号Uniprot:P42574
GeneID:836
Uniprot
P42574
Gene ID
836
实际分子量32KDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts from Mouse lung and Rat liver using CASP3 Antibody.
Immunohistochemistry of paraffin-embedded rat spleen using Caspase-3 antibody.
Immunohistochemistry of paraffin-embedded human tonsil using Caspase-3 antibody.
Immunohistochemistry analysis of paraffin-embedded Human lung cancer using CASP3 Antibody
Immunofluorescence analysis of NIH/3T3 cells using Caspase-3 Rabbit pAb.
Immunofluorescence analysis of PC-12 cells using Caspase-3 Rabbit pAb.
Immunofluorescence analysis of U2OS cells using Caspase-3 Rabbit pAb.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
如果您使用该产品32628发表了文章，请通知我们，让我们可以引用您的文献。
et al,Human urinary kininogenase reduces the endothelial injury by inhibiting Pyk2/MCU pathway. In Biomed Pharmacother on 2021 Nov by Xiaoli Yang, Zhongzhong Li,
et al..PMID:34543986
, (2021),
PMID:
34543986
et al,CD155 Cooperates with PD-1/PD-L1 to Promote Proliferation of Esophageal Squamous Cancer Cells via PI3K/Akt and MAPK Signaling Pathways. In Cancers (Basel) on 2022 Nov 15 by Xiyang Tan, Jie Yang, et al..PMID:36428703
, (2022),
PMID:
36428703
et al,Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation.In Drug Des Devel Ther on 2015 Oct 16 by Jinghua Liu , Jianbo Li et al ..PMID: 26527860
, (2015),
PMID:
26527860
et al,Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin. In Planta Med on 2012 Nov by Xiangyang Yao, Guilan Li, et al..PMID: 22961117
, (2012),
PMID:
22961117
货期一周
