产品详情
产品名称NR3C1 Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total NR3C1 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human Glucocorticoid Receptor (NP_001191194.1).
基因/蛋白名称NR3C1
标记Unconjugated
别名GCCR;GCR;GCRST;GR;GRL;NR3C1
数据库入口号Uniprot:P04150
GeneID:2908
Uniprot
P04150
Gene ID
2908
实际分子量105kDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using Glucocorticoid Receptor antibody.
Immunohistochemistry of paraffin-embedded rat spleen using Glucocorticoid Receptor Rabbit pAb.
Immunohistochemistry of paraffin-embedded human liver cancer using Glucocorticoid Receptor Rabbit pAb.
Immunofluorescence analysis of NIH/3T3 cells using Glucocorticoid Receptor Rabbit pAb.
Immunofluorescence analysis of PC-12 cells using Glucocorticoid Receptor Rabbit pAb.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
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et al,Disrupted development from head to tail: Pervasive effects of postnatal restricted resources on neurobiological, behavioral, and morphometric outcomes. In Front Behav Neurosci on 2022 Aug 5 by Molly H Kent, Joanna C Jacob, et al..PMID: 35990727
, (2022),
PMID:
35990727
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