产品详情
产品名称CCL5 Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB
种属反应性Human
特异性The antibody detects endogenous level of total CCL5 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human CCL5/RANTES (NP_002976.2).
基因/蛋白名称CCL5
标记Unconjugated
别名CCL5;D17S136E;RANTES;SCYA5;SIS-delta;SISd;TCP228;eoCP
数据库入口号Uniprot:P13501
GeneID:6352
Uniprot
P13501
Gene ID
6352
实际分子量13kDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
Western blot analysis of extracts of various cell lines, using CCL5/RANTES antibody.
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.
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et al,Cancer-associated fibroblasts facilitate premetastatic niche formation through lncRNA SNHG5-mediated angiogenesis and vascular permeability in breast cancer. In Theranostics on 2022 Oct 17 by Huan Zeng, Yixuan Hou, et al..PMID:36438499
, (2022),
PMID:
36438499
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