产品详情
产品名称HTR2B Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total HTR2B protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human HTR2B (NP_000858.3).
基因/蛋白名称HTR2B
标记Unconjugated
别名HTR2B;5-HT(2B);5-HT-2B;5-HT2B
数据库入口号Uniprot:P41595
GeneID:3357
Uniprot
P41595
Gene ID
3357
实际分子量47KDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IF 1:10 - 1:100
Western blot analysis of extracts of various cell lines, using HTR2B Rabbit pAb.
Immunofluorescence analysis of U2OS cells using HTR2B antibody.
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene.
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et al,5-HT2A Receptor and 5-HT Degradation Play a Crucial Role in Atherosclerosis by Modulating Macrophage Foam Cell Formation, Vascular Endothelial Cell Inflammation, and Hepatic Steatosis In J Atheroscler Thromb on 2022 Mar 1 by Yingying Ma, Xiurui Liang,et al..PMID: 33536397
, (2022),
PMID:
33536397
et al,Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway. In J Neuroinflammation on 2022 Jan 29 by Yinquan Fang, Xiao Ding, et al..PMID: 35093099
, (2022),
PMID:
35093099
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