产品详情
产品名称FH Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total FH protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human FH (NP_000134.2).
基因/蛋白名称FH
标记Unconjugated
别名FH;FMRD;HLRCC;LRCC;MCL;MCUL1
数据库入口号Uniprot:P07954
GeneID:2271
Uniprot
P07954
Gene ID
2271
实际分子量50kDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100
Western blot analysis of extracts of various cell lines, using FH antibody.
Immunofluorescence analysis of U2OS cells using FH antibody.
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
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et al,GlcNAcylation of fumarase maintains tumour growth under glucose deficiency.
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PMID:
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et al,PAK4 Phosphorylates Fumarase and Blocks TGFβ-Induced Cell Growth Arrest in Lung Cancer Cells. In Cancer Res on 2019 Apr 1 by Chen T, Wang T, et al..PMID:30683654
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30683654
et al,O-GlcNAcylation of Fumarase Maintains Tumour Growth Under Glucose Deficiency .In Nat Cell Biol ON 2017 Jul by Ting Wang , Qiujing Yu,et al..PMID: 28628081
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PMID:
28628081
et al,Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.In Nat Cell Biol on 2015 Sep by Yuhui Jiang, Xu Qian et al..PMID:26237645
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26237645
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