产品详情
产品名称HPSE Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total HPSE protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant protein of human HPSE.
基因/蛋白名称HPSE
标记Unconjugated
别名HPA; HPA1; HPR1; HSE1; HPSE1
数据库入口号Swiss-Prot:Q9Y251
NCBI Gene ID:10855
Uniprot
Q9Y251
实际分子量61KD
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IF 1:10 - 1:100
Western blot analysis of extracts of various cell lines, using Heparanase 1 antibody at 1:1000 dilution.
Immunofluorescence analysis of U2OS cells using Heparanase 1 antibody. Blue: DAPI for nuclear staining.
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.
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et al,Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF-κB/HPSE1 Signaling Pathway During Inflammation. In Front Pharmacol on 2022 Jan 3 by Jin Lei, Peng Xiang, et al..PMID:35185540
, (2022),
PMID:
35185540
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