产品详情
产品名称ANP32A Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total ANP32A protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human ANP32A (NP_006296.1).
基因/蛋白名称ANP32A
标记Unconjugated
别名ANP32A;C15orf1;HPPCn;I1PP2A;LANP;MAPM;PHAP1;PHAPI;PP32
数据库入口号Uniprot:P39687
GeneID:8125
Uniprot
P39687
Gene ID
8125
实际分子量28kDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using ANP32A antibody.
Immunohistochemistry of paraffin-embedded rat kidney using ANP32A Antibody.
Immunohistochemistry of paraffin-embedded human breast cancer using ANP32A Antibody.
Immunohistochemistry of paraffin-embedded mouse brain using ANP32A Antibody.
Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition. Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R. Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A.
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PMID:
33372534
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