产品详情
产品名称TFRC Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total TFRC protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant protein of human TFRC.
基因/蛋白名称TFRC
标记Unconjugated
别名T9; TR; TFR; p90; CD71
数据库入口号Swiss-Prot:P02786
NCBI Gene ID:7037
Uniprot
P02786
实际分子量84KD
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using TFRC antibody at 1:3000 dilution.
Immunofluorescence analysis of L929 cells using TFRC Polyclonal antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat kidney using TFRC antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver cancer using TFRC antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human colon carcinoma using TFRC antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human placenta using TFRC antibody at dilution of 1:100 (40x lens).
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
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et al,PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration.
, (2025),
PMID:
39893206
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