产品详情
产品名称UGT1A1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total UGT1A1 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant protein of human UGT1A1.
基因/蛋白名称UGT1A1
标记Unconjugated
别名GNT1; UGT1; UDPGT; UGT1A; HUG-BR1
数据库入口号Swiss-Prot:P22309
NCBI Gene ID:54658
Uniprot
P22309
实际分子量60KD
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Immunofluorescence analysis of Rat liver using UGT1A1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of U2OS cells using UGT1A1 antibody. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of Human liver cancer using UGT1A1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of Mouse liver using UGT1A1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
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et al,Constitutive Androstane Receptor in Macrophages Regulates Toll‐Like Receptor 4‐Mediated Innate Immune Responses Against Endotoxemic Liver Injury
, (2025),
PMID:
40820881
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