产品详情
产品名称Bak Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB IHC IF
种属反应性Human
特异性The antibody detects endogenous levels of total Bak protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from human Bak.
基因/蛋白名称Bak
标记Unconjugated
别名Bcl-2 homologous antagonist/killer; Apoptosis regulator BAK; Bcl-2-like 7 protein; BAK1; BAK
数据库入口号Swiss-Prot: Q16611
NCBI Gene ID: 578
Uniprot
Q16611
实际分子量25kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from 293 cells, using Bak antibody #33326.
Immunohistochemical analysis of paraffin-embedded human skeletal muscle tissue using Bak antibody #33326.
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.
Takuma Uo, J. Biol. Chem., Mar 2005; 280: 9065 - 9073.
Pierre-Fran?ois Cartron, Mol. Cell. Biol., Jul 2003; 23: 4701 - 4712.
Joslyn K. Brunelle, J. Biol. Chem., Feb 2004; 279: 4305 - 4312.
Neil A. Jones, Mol. Pharmacol., May 1998; 53: 819.
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et al,IFN-γ restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer. In Cell Death Dis on 2019 Sep 9 by Huijing Yin, Zhengyu Jiang, et al..PMID: 31501431
, (2019),
PMID:
31501431
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