产品详情
产品名称Collagen IV Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB;IHC;IF/ICC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total Collagen IV protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from human Collagen IV.
基因/蛋白名称Collagen IV
标记Unconjugated
别名COL4A1 NC1 domain; COLLAGEN OF BASEMENT MEMBRANE; ALPHA-1 CHAIN ARRESTEN; alpha 1 type IV collagen preproprotein; collagen IV alpha-1 polypeptide
数据库入口号Swiss-Prot: P02462
NCBI Gene ID: 1282
Uniprot
P02462
实际分子量160kd
浓度1.0mg/ml
配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
保存Store at -20˚C
应用详情
WB 1:500-1:2000;
IHC 1:100-1:300;
ICC/IF 1:50-1:200
Western Blot analysis of mouse-musle cells using COL4A1 Polyclonal Antibody diluted at 1:500
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Collagen IV Antibody. The picture on the right is blocked with the synthesized peptide.
Prenatal bisphenol S exposure induces hepatic lipid deposition in male mice offspring through downregulation of adipose-derived exosomal miR-29a-3p JOURNAL OF HAZARDOUS MATERIALS Guizhen Du IF Mouse AML12 hepatocytes
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
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et al,Three-Dimensional Culture Promotes Secretion of Extracellular Matrix Structure Fat Flap with Lipoaspirates in Vitro. In Tissue Eng Part A
on 2022 Nov by Jing Zhao, Xin Bi,et al..PMID: 36017621
, (2022),
PMID:
36017621
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