产品详情
产品名称FAP-1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total FAP-1 protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from human FAP-1.
基因/蛋白名称FAP-1
标记Unconjugated
别名DPPIV; FAPA; SEPRASE; fibroblast activation protein alpha subunit; integral membrane serine protease
数据库入口号Swiss-Prot: Q12884
NCBI Gene ID: 2191
Uniprot
Q12884
实际分子量88kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FAP-1 antibody #33369.
Western blot analysis of extracts from LOVO cells, using FAP-1 antibody #33369.
Western blot analysis of extracts from colo cells (Lane 2), using FAP-1 antiobdy #33369. The lane on the left is treated with synthesized peptide.
In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.
Hendrik Ungefroren, J. Cell Sci., Aug 2001; 114: 2735.
Vladimir N. Ivanov, Mol. Cell. Biol., May 2003; 23: 3623 - 3635.
Vladimir N. Ivanov, J. Biol. Chem., Jan 2006; 281: 1840 - 1852.
T Sato, ience, Apr 1995; 268: 411 - 415.
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et al,Ultrasensitive fluorescent probes reveal an adverse action of dipeptide peptidase IV and fibroblast activation protein during proliferation of cancer cells.In Anal Chem on 2016 Aug 16 by Qiuyu Gong, Wen Shi et al..PMID:27444320
, (2016),
PMID:
27444320
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