产品详情
产品名称MART-1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total MART-1 protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from human MART-1.
基因/蛋白名称MART-1
标记Unconjugated
别名MART-1; MART1; melan-A; MELAN A; MELANOMA ANTIGEN RECOGNIZED BY T CELLS 1
数据库入口号Swiss-Prot: Q16655
NCBI Gene ID: 2315
Uniprot
Q16655
实际分子量15kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from NIH/3T3 cells, using MART-1 antibody #33429.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MART-1 antibody #33429.
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Toshihiko Hoashi, J. Biol. Chem., Apr 2005; 280: 14006 - 14016.
Maria P. Bettinotti, J. Immunol., Jul 1998; 161: 877.
P. J. Frost, J. Immunol., Mar 2001; 166: 3564.
Flora Wang, Clin. Cancer Res., Oct 1999; 5: 2756.
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et al,Targeting p63 upregulation abrogates resistance to MAPK inhibitors in melanoma.In Cancer Res on 2020 Apr 14. by Patel A, Fraile Garcia L, et al..PMID:32291316
, (2020),
PMID:
32291316
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