产品详情
产品名称MCL1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total MCL1 protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from human MCL1.
基因/蛋白名称MCL1
标记Unconjugated
别名EAT/MCL-1 protein; Induced myeloid leukemia cell differentiation protein Mcl-1; Myeloid cell leukemia sequence 1.;
数据库入口号Swiss-Prot: Q07820
NCBI Gene ID: 4170
Uniprot
Q07820
实际分子量37kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MCL1 antibody #33430.
Western blot analysis of extracts from HuvEc cells, using MCL1 antibody #33430.
Western blot analysis of extracts from HuvEc cells (Lane 2), JK cells (Lane 3) and cos-7 cells (Lane 4), using MCL1 antiobdy #33430. The lane on the left is treated with synthesized peptide.
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Alfredo De Biasio, J. Biol. Chem., Jun 2007; 10.1074.
Potchanapond Graidist, J. Biol. Chem., Sep 2004; 279: 40868 - 40875.
Kenichi Fujise, J. Biol. Chem., Dec 2000; 275: 39458.
Di Zhang, J. Biol. Chem., Sep 2002; 277: 37430 - 37438.
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et al,Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma. In PLoS One on 2012 by Manujendra N Saha, Hua Jiang, et al..PMID:
22276160
, (2012),
PMID:
22276160
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