产品详情
产品名称NRF2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB IHC IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total NRF2 protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from human NRF2.
基因/蛋白名称NRF2
标记Unconjugated
别名HEBP1; NF-E2 related factor 2; NF2L2; NFE2-related factor 2; NFE2L2
数据库入口号Swiss-Prot: Q16236
NCBI Gene ID: 4780
Uniprot
Q16236
计算分子量68kda
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500
Western blot analysis of extracts from HuvEc cells, using NRF2 antibody #33450.
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using NRF2 antibody #33450.
Immunofluorescence analysis of HuvEc cells, using NRF2 antibody #33450.
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Rajesh K. Thimmulappa, J. Clin. Invest., Apr 2006; 116: 984 - 995.
Sara B. Cullinan, Mol. Cell. Biol., Oct 2003; 23: 7198 - 7209.
Tirumalai Rangasamy, J. Exp. Med., Jul 2005; 202: 47 - 59.
Wenge Li, J. Biol. Chem., Aug 2005; 280: 28430 - 28438.
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et al,Artemisinin protected human bronchial epithelial cells from amiodarone-induced oxidative damage via 5'-AMP-activated protein kinase (AMPK) activation.
, (2025),
PMID:
39803706
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