产品详情
产品名称P300/CBP Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total P300/CBP protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from human P300/CBP.
基因/蛋白名称P300/CBP
标记Unconjugated
别名CAF; PCAF; P/CAF；KAT2B
Uniprot
Q92831
Gene ID
8850
实际分子量93kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.
Gerd A. Blobel, J. Leukoc. Biol., Apr 2002; 71: 545.
Eric Kalkhoven, Hum. Mol. Genet., Feb 2003; 12: 441 - 450.
Wei-fang Shen, Mol. Cell. Biol., Nov 2001; 21: 7509 - 7522.
Frederick C. Nucifora, Science, Mar 2001; 291: 2423.
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