产品详情
产品名称Presenilin 1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total presenilin 1 protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from human presenilin 1.
基因/蛋白名称Presenilin 1
标记Unconjugated
别名AD3; AD3H; PS-1; PS1; PSN1
数据库入口号Swiss-Prot: P49768
NCBI Gene ID: 5663
Uniprot
P49768
实际分子量60kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from mouse heart cells, using presenilin 1 antibody #33474.
Immunohistochemical analysis of paraffin-embedded human brain tissue using presenilin 1 antibody #33474.
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
Yanzhu Liu, J. Lipid Res., Dec 2004; 45: 2368 - 2376.
I. Imafuku, J. Cell Biol., Oct 1999; 147: 121.
Angeliki Louvi, Development, Jul 2004; 131: 3093 - 3105.
Wim G. Annaert, J. Cell Biol., Oct 1999; 147: 277.
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et al,Oral Treponema denticola Infection Induces A尾1锟?0 and A尾1锟?2 Accumulation in the Hippocampus of C57BL/6 Mice. In J Mol Neurosci on 2021 Jul by Xinyi Su 1, Zhiqun Tang, et al..PMID: 33763842
, (2021),
PMID:
33763842
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