产品详情
产品名称HBP1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total HBP1 protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from Internal of human HBP1.
基因/蛋白名称HBP1
标记Unconjugated
别名HMG box-containing protein 1; HMG box-containing protein 1; High mobility group box transcription factor 1; HBP1;
数据库入口号Swiss-Prot: O60381
NCBI Gene ID: 26959
Uniprot
O60381
实际分子量57kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Western blot analysis of extracts from COS-7 cells, using HBP1 antibody #33596.
Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
Lemercier C., Mol. Cell. Biol. 20:6627-6637(2000).
Hillier L.W., Nature 424:157-164(2003).
Ota T., Nat. Genet. 36:40-45(2004).
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et al,Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve.In Cell Death Differ on 2016 Oct by Z Dong , M Huang et al..PMID:27206316
, (2016),
PMID:
27206316
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