产品详情
产品名称TNFA Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用IHC IF
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total TNFA protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from internal of human TNFA.
基因/蛋白名称TNFA
标记Unconjugated
别名Protein name Tumor necrosis factor [Precursor]; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin
数据库入口号Swiss-Prot: P01375
NCBI Gene ID: 7124
Uniprot
P01375
实际分子量26kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using TNFA antibody #33648.
Immunofluorescence analysis of HepG2 cells, using TNFA antibody #33648.
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
Neville M.J., J. Immunol. 162:4745-4754(1999).
Xie T., Genome Res. 13:2621-2636(2003).
Kim Y.J., Hum. Mol. Genet. 12:2541-2546(2003).
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et al,Lactobacillus reuteri Alleviates Hyperoxia-Induced BPD by Activating IL-22/STAT3 Signaling Pathway in Neonatal Mice
, (2024),
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