产品详情
产品名称HMGB1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total HMGB1 protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from internal of human HMGB1.
基因/蛋白名称HMGB1
标记Unconjugated
别名HMG-1; HMG1; High mobility group protein 1; SBP-1; amphoterin
数据库入口号Swiss-Prot: P09429
NCBI Gene ID: 3146
Uniprot
P09429
实际分子量25kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Western blot analysis of extracts from Jurkat cells, HepG2 cells, COLO205 cells and 293 cells, using HMGB1 antibody #33661.
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells By similarity.
Wen L., Nucleic Acids Res. 17:1197-1214(1989).
Ferrari S., Genomics 35:367-371(1996).
Rasmussen R.K., Electrophoresis 18:588-598(1997).
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et al,Biodegradable iridium coordinated nanodrugs potentiate photodynamic therapy and immunotherapy of lung cancer.
, (2025),
PMID:
39488900
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