产品详情
产品名称JAK1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用IHC IF
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total JAK1 protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from internal of human JAK1.
基因/蛋白名称JAK1
标记Unconjugated
别名EC 2.7.10.2; JAK-1; JAK1; JAK1A; Janus kinase 1
数据库入口号Swiss-Prot: P23458
NCBI Gene ID: 3716
Uniprot
P23458
实际分子量130kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using JAK1 antibody #33721.
Immunofluorescence analysis of HeLa cells, using JAK1 antibody #33721.
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
Wilks A.F., Mol. Cell. Biol. 11:2057-2065(1991).
Lee S.-T., Oncogene 8:3403-3410(1993).
Lindholm C.K., Biochem. Biophys. Res. Commun. 296:929-936(2002).
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et al,Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase
, (2017),
PMID:
29371942
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