产品详情
产品名称TEAD2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用IHC IF
种属反应性Human
特异性The antibody detects endogenous levels of total TEAD2 protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from internal of human TEAD2.
基因/蛋白名称TEAD2
标记Unconjugated
别名TEA domain family member 2; TEAD-2;
数据库入口号Swiss-Prot: Q15562
NCBI Gene ID: 8463
Uniprot
Q15562
实际分子量49kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TEAD2 antibody #33900.
Immunofluorescence analysis of HepG2 cells, using TEAD2 antibody #33900.
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Jacquemin P., J. Biol. Chem. 271:21775-21785(1996).
如果您使用该产品33900发表了文章，请通知我们，让我们可以引用您的文献。
et al,Thyroid hormone regulates muscle fiber type conversion via miR-133a1. In J Cell Biol on 2014 Dec 22 by Duo Zhang, Xiaoyun Wang,
et al..PMID: 25512392
, (2014),
PMID:
25512392
有货
