产品详情
产品名称14-3-3 η Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total 14-3-3 η protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from internal of human 14-3-3 η.
基因/蛋白名称14-3-3 η
标记Unconjugated
别名14-3-3 protein eta; Protein AS1; YWHAH; YWHA1;
数据库入口号Swiss-Prot: Q04917
NCBI Gene ID: 7533
Uniprot
Q04917
实际分子量42kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Immunofluorescence: 1:100~1:500
Western blot analysis of extracts from Jurkat cells, using 14-3-3 η antibody #34146.
Immunofluorescence analysis of HeLa cells, using 14-3-3 η antibody #34146.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Swanson K.D., Biochim. Biophys. Acta 1216:145-148(1993).
Ichimura-Ohshima Y., J. Neurosci. Res. 31:600-605(1992).
Muratake T., Mol. Neurobiol. 11:223-230(1995).
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et al,Cytoplasmic expression of p33ING1b is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma. In Histol Histopathol on 2011 May by Xiao-Han Li, Akira Noguchi, et al..PMID: 21432775
, (2011),
PMID:
21432775
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