产品详情
产品名称CHP2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total CHP2 protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from internal of humanCHP2.
基因/蛋白名称CHP2
标记Unconjugated
别名Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520; CHP2; HCA520;
数据库入口号Swiss-Prot: O43745
NCBI Gene ID: 63928
Uniprot
O43745
实际分子量22kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Western blot analysis of extracts from Jurkat cells, K562 cells and HT-29 cells, using CHP2 antibody.The lane on the right is treated with synthesized peptide
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
Loftus B.J., Genomics 60:295-308(1999).
Wang Y., J. Immunol. 169:1102-1109(2002).
Pang T., J. Biol. Chem. 277:43771-43777(2002).
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et al,CHP2 Promotes Cell Proliferation in Breast Cancer via Suppression of FOXO3a.In Mol Cancer Res.On 2018 Oct by Zhao X, Xie T et al..PMID: 29967111
, (2018),
PMID:
29967111
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