产品详情
产品名称BCL2A1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total BCL2A1 protein.
免疫原类型Recombinant Protein
免疫原描述Fusion protein corresponding to a region derived from internal residues of human BCL2-related protein A1
基因/蛋白名称BCL2A1
标记Unconjugated
别名GRS; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5
数据库入口号Swiss-Prot#: Q16548
NCBI Gene ID: 597
Gene Accssion: BC016281
Uniprot
Q16548
实际分子量20kd
浓度0.7mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:25-1:100
Gel: 12%SDS-PAGE
Lysates (from left to right): Mouse testis tissue and hela cell
Amount of lysate: 40ug per lane
Primary antibody: 1/117 dilution
Secondary antibody dilution: 1/8000
Exposure time: 1 minute
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #35596 at dilution 1/20.
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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et al,KCNN4 induces multiple chemoresistance in breast cancer by regulating BCL2A1. In Am J Cancer Res on 2020 Oct 1 by Peiyang Lin, Junjing Li,et al..PMID:33163271
, (2020),
PMID:
33163271
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