产品详情
产品名称CTSE Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total CTSE protein.
免疫原类型Recombinant Protein
免疫原描述Fusion protein corresponding to a region derived from internal residues of human Cathepsin E
基因/蛋白名称CTSE
标记Unconjugated
别名CATE
数据库入口号Swiss-Prot#: P14091
NCBI Gene ID: 1510
Gene Accssion: BC042537
Uniprot
P14091
实际分子量43kd
浓度0.28mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:100-1:500
Immunohistochemistry: 1:25-1:100
Gel: 8%SDS-PAGE
Lysates (from left to right): Human stomach cancer tissue
Amount of lysate: 40ug per lane
Primary antibody: 1/140 dilution
Secondary antibody dilution: 1/8000
Exposure time: 30 seconds
Immunohistochemical analysis of paraffin-embedded Human pancreatic cancer tissue using #35666 at dilution 1/10.
The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.
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et al,Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals potential therapeutic strategies. In Nat Commun on 2022 Nov 8 by Yan Li, Chen Xu, et al..PMID: 36347856
, (2022),
PMID:
36347856
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